Week 16, 2025 season•Mon, Dec 22, 2025•8:15PM ET

San Francisco 49ers 48, Indianapolis Colts 27 (Final)

San Francisco 49ers team logoSFO48
Market spread: IND +6.5Market total: 46.5
Indianapolis Colts team logoIND27

Pre-game model win probability

San Francisco 49ers41%
Indianapolis Colts59%

The share of our drive-by-drive simulations of this game that each team wins, computed before kickoff. How the model works

Predictions & Analytics

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